Yes, as long as you have a jigsaw and a super fine blade for Plexiglas. What I did was use a sharpie to mark the cut. Then I put 2 inch masking tape over the mark. I measured again and put the sharpie line over the masking tape (at center). You'll see the sharpie line transposes over the line you made on the plastic through the masking tape if you use the beige. Blue tape is harder to see. If you have a helper, that would be best, otherwise you'll have to clamp it to something to stabilize the cut. I used a thin piece of Luan under my cut lines. If you have a piece of plywood at 1/4 inch-that will work. Go medium speed- not high at first, then increase the speed through the entire cut. The main thing is to ensure the cutting line doesn't move if cutting freehand-or- you can "fence" the area with a 4 foot level as well with clamps. Once you're done, simply remove the masking tape for your nice clean cut. tried and true...never fails. :-)
With some chipping.
I believe so. mine fit so there was room to expand or contract.